منابع مشابه
The Incentive Salience of Alcohol
Results: Findings indicate that the C allele of rs2023239 is associated with greater CB1 binding in the prefrontal cortex, greater alcohol cue–elicited brain activation in the midbrain and prefrontal cortex, greater subjective reward when consuming alcohol, and more positive outcomes after treatment with a medication that targets the mesocorticolimbic neurocircuitry. In addition, there were str...
متن کاملThe incentive salience of alcohol: translating the effects of genetic variant in CNR1.
CONTEXT The gene that codes for cannabinoid receptor 1 (CNR1) represents an important target for investigations designed to elucidate individual differences in the etiology of alcohol dependence. OBJECTIVE To achieve a better understanding of the role of the CNR1 gene in the etiology and treatment of alcohol dependence. DESIGN The present investigation spans multiple levels of analysis, inc...
متن کاملIndividual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue
Individual differences exist in the attribution of incentive salience to conditioned stimuli associated with food. Here, we investigated whether individual differences also manifested with a Pavlovian alcohol conditioned stimulus (CS). We compiled data from five experiments that used a Pavlovian autoshaping paradigm and tests of conditioned reinforcement. In all experiments, male, Long-Evans ra...
متن کاملIncentive Salience and the Transition to Addiction
Most adults have used a potentially addictive drug at least once in their lifetime, if caffeine, alcohol, and nicotine are included in addition to illicit drugs. In some cases, contact with a substance is so frequent and socially accepted that many in society fail to recognize it as a “drug.” However, relatively few people develop sufficient problems with drug use to meet the formal criteria fo...
متن کاملA Neural Computational Model of Incentive Salience
Incentive salience is a motivational property with 'magnet-like' qualities. When attributed to reward-predicting stimuli (cues), incentive salience triggers a pulse of 'wanting' and an individual is pulled toward the cues and reward. A key computational question is how incentive salience is generated during a cue re-encounter, which combines both learning and the state of limbic brain mechanism...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2008
ISSN: 0003-990X
DOI: 10.1001/archpsyc.65.7.841